![]() ![]() Furthermore, the speed of glaucoma progression as measured by OCT, such as NFL and macular ganglion cell complex (GCC) thinning in µm/year poorly correlates with the rate of VF changes as measured in MD trend in dB/year or Visual Field Index (VFI) trend in %/year 8, 9, 10, 11, 12. But the overall peripapillary nerve fiber layer (NFL) thickness correlates poorly with VF mean deviation (MD) 6, 7. Quantitative imaging of the optic nerve head (ONH) and retina with optical coherence tomography (OCT) 3 are widely used in diagnosis and monitoring of glaucoma 4, 5. However, VF testing is subjective, time-consuming, and poorly reproducible. Visual field (VF) test is the current standard to monitor glaucoma progression. This allows the rational use of medical, laser, and surgical treatments, all of which have significant cost, compliance, and safety issues. Glaucoma is a leading cause of blindness 1, 2, and effective glaucoma management requires early detection, followed by careful evaluation and monitoring to identify those at the highest risk for disease progression and vision loss. It agrees well with VF_MD in early glaucoma but underestimates damage in moderate~advanced stages. It has better reproducibility than VF_MD, which may be advantageous in detecting progression. In summary, OCT-based NFL_MD has better correlation with VF_MD and greater diagnostic sensitivity than the average NFL thickness. NFL_MD had better reproducibility than VF_MD (0.35 vs 0.69 dB, p < 0.001). NFL_MD also had significantly higher sensitivity in detecting PPG (0.14 vs 0.08) and PG (0.60 vs 0.43) at the 99% specificity level. NFL_MD had significantly higher correlation (Pearson R: 0.68 vs 0.55, p < 0.001) with VF_MD than the overall NFL thickness. From the Advanced Imaging for Glaucoma study, 245 normal, 420 pre-perimetric glaucoma (PPG), and 289 perimetric glaucoma (PG) eyes were selected. The NFL_MD parameter in dB scale was calculated from the peripapillary NFL thickness profile nonlinear transformation and VF area-weighted averaging. To construct an optical coherence tomography (OCT) nerve fiber layer (NFL) parameter that has maximal correlation and agreement with visual field (VF) mean deviation (MD). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |